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December 8, 2025BloodOpen Access

Lymphoma are the most frequent secondary hematologic malignancies following solid tumors: A large cohort study from the german cancer registry nrw

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Authors

ATAmin TurkiIWIna WellmannHKHiltraud Kajüter

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Implication

Cohort study identifies non-Hodgkin's lymphoma as frequent SHM after solid tumors, indicating risks for adolescents and men.

Key Points

  • This study investigates secondary hematologic malignancies following solid cancer diagnoses and their characteristics.
  • Data from the North Rhine-Westphalia Cancer Registry from 2008-2023 was analyzed.
  • Patients aged 15 and older with hematologic malignancies following solid cancer were included.
  • Only cases with at least 6 months gap after solid cancer diagnosis were analyzed.
  • Standardized Incidence Ratios (SIR) were calculated for observed SHM cases compared to the general population.
  • Among 1,426,752 diagnosed cancer patients, 8,709 cases of SHM were identified.
  • The most common SHM was non-Hodgkin's lymphoma, followed by myeloma and chronic lymphocytic leukemia.
  • The peak age for SHM diagnosis was 75 years, with significant sex differences in diagnoses.
  • Adolescents and young adults showed the highest SIR for SHM, indicating age-related vulnerability.

Cite This Study

Turki et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d50bhttps://doi.org/10.1182/blood-2025-4519
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Also Consider

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  1. 1Sex-stratified risk of second malignancies in Hodgkin lymphoma survivors: A retrospective study.2026
  2. 2Subsequent malignant neoplasms after primary hematological malignancy in adult patients2024 · 4 citations
  3. 3Sex-stratified risk of second malignancies in Hodgkin lymphoma survivors: A SEER-based analysis of latency and cancer type.2025
  4. 4Secondary hematologic malignancy mortality in older survivors of gastrointestinal cancer.2026
  5. 5Proportion of second hematologic malignancies linked to radiotherapy treatment in adults: A cohort study in the US SEER cancer registries 2001-20222025