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December 8, 2025Blood

Mortality trends in chronic myeloid leukemia in the United States: A population-based analysis

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Authors

HYHumna YounisFRFaisal RiazSMShaheer Minhas

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Overview

Retrospective analysis reveals declining mortality trends in CML, suggesting significant disparities by race and gender.

Key Points

  • The aim is to analyze mortality trends in Chronic Myeloid Leukemia (CML) across various socio-demographic subgroups.
  • Retrospective analysis using CDC WONDER death certificate data from 1999 to 2020
  • Focus on CML death causes identified by ICD-10 code C92.1
  • Data stratified by sex, race/ethnicity, and census region
  • Statistical analysis calculated Age-Adjusted Mortality Rate (AAMR), Annual Percentage Change (APC), Average Annual Percentage Change (AAPC) using joinpoint regression
  • 32,484 CML-related deaths recorded from 1999 to 2020
  • AAMR decreased from 1.45 to 0.63 per 100,000
  • Males consistently had higher AAMRs than females
  • Racial disparities observed in AAMR rates among different ethnic groups
  • Slight increase in AAMR noted from 2018 to 2020 across all groups

Cite This Study

Younis et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d525https://doi.org/10.1182/blood-2025-7289
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