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December 8, 2025BloodOpen Access

Impact of minimal residual disease and next generation sequencing discordance in AML following induction with hypomethylating agent + venetoclax.

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Authors

PCPatton CrokerMedical University of South Carolina JAJean-Sebastien AnomaMedical University of South Carolina JAJonathan AlexánderUniversity of Hawaiʻi at Mānoa

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Implication

Retrospective analysis shows treatment with hypomethylating agents and venetoclax affects survival rates in AML, highlighting minimal residual disease significance.

Key Points

This research investigates the impact of minimal residual disease and next generation sequencing on outcomes in acute myeloid leukemia (AML).
Retrospective single center study of AML patients treated with hypomethylating agent and venetoclax
Patients stratified by MRD and NGS results for overall survival and relapse free survival analysis
Cox proportional hazards model was used to analyze associations between MRD/NGS groups and survival outcomes.
Median overall survival was highest in MRD(-)/NGS(+) group at 909 days
MRD(+)/NGS(+) group had median OS of 158 days
RFS was significantly correlated with MRD/NGS classification, with MRD(+)/NGS(+) showing highest hazard ratio for relapse

Cite This Study

Croker et al. (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d5c5 https://doi.org/10.1182/blood-2025-7047

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Implication

Retrospective analysis shows treatment with hypomethylating agents and venetoclax affects survival rates in AML, highlighting minimal residual disease significance.

Impact of minimal residual disease and next generation sequencing discordance in AML following induction with hypomethylating agent + venetoclax.

Discussion

Member takes

Implication

Key Points

Cite This Study

Impact of minimal residual disease and next generation sequencing discordance in AML following induction with hypomethylating agent + venetoclax.

Discussion

Member takes

Implication

Key Points

Cite This Study

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