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December 8, 2025Blood

Arginine deprivation activates immunogenic cell death and enhances anti-tumor immunity in diffuse large B-cell lymphoma

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Authors

FSFeng Shi

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Overview

Arginine deprivation therapy induces immunogenic cell death in DLBCL, highlighting its potential for anti-tumor immunity.

Key Points

  • Investigating the effects of arginine deprivation therapy on immunogenic cell death and anti-tumor immunity in diffuse large B-cell lymphoma.
  • Performed untargeted metabolomic profiling on DLBCL serum from patients and healthy volunteers.
  • Evaluated therapeutic efficacy of arginine deprivation therapy (ADT) in DLBCL models.
  • Conducted RNA-seq to analyze cellular mechanisms post-therapy.
  • Assessed immune response through prophylactic vaccination models.
  • Investigated metabolic pathways altered by ADT, including PD-L1 expression changes.
  • ADT induced immunogenic cell death in DLBCL, characterized by ROS production and increased calreticulin exposure.
  • Significant depletion of serum arginine levels was observed in DLBCL patients, revealing cellular dependence on exogenous arginine.
  • Prophylactic vaccination with ADT-pretreated cells enhanced anti-tumor immunity and delayed tumor growth.
  • Combination of ADT with PD-1 blockade provided superior tumor control compared to individual therapies.

Cite This Study

Feng Shi (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d607https://doi.org/10.1182/blood-2025-3298
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