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December 8, 2025BloodOpen Access

Adenosine pathway as a therapeutic target in diffuse large B cell lymphoma

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Authors

MMMiranda McGaskeyECEthel Cesarman

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Overview

Preclinical model demonstrates that A2AR antagonists can improve survival in DLBCL via tumor immunity mechanisms.

Key Points

  • This research examines the role of the adenosine pathway in diffuse large B cell lymphoma (DLBCL) and its potential as a therapeutic target.
  • Examined expression of A2AR, CD39, and CD73 using RNA sequencing and immunohistochemistry in DLBCL samples.
  • Performed immunoblotting to evaluate functional A2AR in DLBCL cell lines.
  • Used phosphokinase arrays to analyze downstream signaling from A2AR activation.
  • Conducted in vivo studies using adoptive transfer of tumors in NOD-SCID and B6 mice to evaluate effects of A2AR inhibitor ciforadenant.
  • Higher expression of CD39 in ABC-DLBCL compared to GC-DLBCL, with variable expression of CD73.
  • Ciforadenant treatment improved survival in B6 mice, while NOD-SCID mice showed no significant tumor responses.
  • DLBCL cells demonstrated resistance to eADO-induced immunosuppression seen in normal B cells.

Cite This Study

McGaskey et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db3fhttps://doi.org/10.1182/blood-2025-5345
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Also Consider

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  1. 1Arginine deprivation activates immunogenic cell death and enhances anti-tumor immunity in diffuse large B-cell lymphoma2025
  2. 2Abstract 161: Adenosine signaling promotes double-negative t-cell anticancer responses in conditions of CD8 t-cell lymphopenia.2026
  3. 3Effect of AVM0703 treatment on the limitations of R-CHOP and survival in a model applicable to ABC subtype DLBCL.2024
  4. 4517 Dual roles of β2-adrenergic signaling in the progression of acute myeloid leukemia2026
  5. 5A2AR-mediated inhibition of B cell maturation: a novel mechanism of immune suppression in cancer2025