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December 8, 2025BloodOpen Access

Thrombotic thrombocytopenic purpura-related mortality trends among the United States population: A retrospective study using the CDC wonder database

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Authors

MKMehandar Kumar

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Overview

Retrospective analysis reveals declines in TTP-related mortality trends by race and geography.

Key Points

  • To analyze mortality trends related to thrombotic thrombocytopenic purpura in the US population over a 22-year period.
  • Conducted a retrospective analysis using the CDC WONDER database from 1999 to 2020.
  • Identified TTP-related deaths using ICD-10 code M31.1 and calculated age-adjusted mortality rates (AAMRs).
  • Data were stratified by demographics, urbanization, geographic region, and place of death.
  • Used Joinpoint Regression to evaluate temporal trends in AAMR and assess model fit.
  • A total of 7,820 TTP-related deaths were recorded from 1999 to 2020, with AAMR declining from 0.20 to 0.07 per 100,000 population.
  • The Joinpoint regression model showed a strong fit (R² = 0.87) and identified four temporal segments of mortality decline.
  • Significant mortality disparities were found by sex, race, and geographic region, with females and Black individuals experiencing higher AAMRs.

Cite This Study

Mehandar Kumar (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d62bhttps://doi.org/10.1182/blood-2025-1332
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