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December 8, 2025BloodOpen Access

Ethnic, racial, and geographic disparities in idiopathic thrombocytopenic purpura related mortality along the US-Mexico border from 1999 to 2020

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Authors

AKAllahdad KhanSASiti Rozaimah Sheikh Abdullah

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Overview

Analysis of mortality rates for ITP in diverse populations, highlighting rural-urban differences and implications for care access.

Key Points

  • To analyze disparities in idiopathic thrombocytopenic purpura-related mortality along the US-Mexico border from 1999 to 2020.
  • Analyzed CDC WONDER Multiple Cause of Death database for ITP-related mortality (ICD-10: D69.3)
  • Computed crude mortality rates (CMRs) and age-adjusted mortality rates (AAMRs)
  • Stratified data by years, sex, race/ethnicity, urbanization status, and age groups
  • Estimated average annual percent changes (AAPCs) using joinpoint regression
  • 15,660 deaths reported from ITP in the US-Mexico Border Regions between 1999-2020
  • AAMR decreased from 0.29 in 1999 to 0.18 in 2020
  • Men had higher AAMR (0.25) than women (0.19)
  • NH Whites had the highest AAMR of 0.22, while Hispanics had 0.18
  • Rural areas showed higher AAMR (0.24) compared to urban areas (0.21)

Cite This Study

Khan et al. (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dd19https://doi.org/10.1182/blood-2025-7991
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Also Consider

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  1. 1Trends and disparities in immune thrombocytopenic purpura-related mortality in the United States: a retrospective study over 24 years2025
  2. 2Thrombotic thrombocytopenic purpura-related mortality trends among the United States population: A retrospective study using the CDC wonder database2025
  3. 3The unseen bleed- temporal and demographic patterns of thrombocytopenia mortality in the United States: A 25-year analysis of the CDC wonder database2025
  4. 4Rapid decrease in age-adjusted mortality rates associated with ITP following eltrombopag aand romiplostin approvals, but not in TMA following eculizumab approval, 1999-20232025
  5. 5Disparities in autoimmune hemolytic Anemia–Related mortality in the u.S.–Mexico border region, 1999–2020: A CDC wonder study.2025