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December 8, 2025BloodOpen Access

Rapid decrease in age-adjusted mortality rates associated with ITP following eltrombopag aand romiplostin approvals, but not in TMA following eculizumab approval, 1999-2023

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Authors

EZEli Zolotov

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Overview

Analysis reveals a significant decline in ITP mortality post-eltrombopag and romiplostim approval, highlighting drug impact.

Key Points

  • This research examines mortality trends for ITP, TMA, and DIC from 1999 to 2023, particularly after drug approvals.
  • Utilized CDC WONDER database for national mortality trends
  • Analyzed age-adjusted mortality rates (AAMR) for ITP, TMA, and DIC
  • Considered stratification by census region, sex, and race
  • AAMR for ITP dropped from 1.74 (1999) to 0.39 (2023) after eltrombopag approval
  • AAMR for TMA decreased consistently with no sharp change post-Eculizumab approval
  • DIC AAMR showed a gradual decline from 3.52 (1999) to 2.24 (2023)

Cite This Study

Eli Zolotov (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236e008https://doi.org/10.1182/blood-2025-4467
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