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December 8, 2025Blood

Hemostasis in crisis: Two-decade trends of mortality due to coagulation defects in the u.S. population; A CDC- wonder database analysis

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Authors

HTHaseeb TareenWAW. S. H. Munirah W AhmadMSMuhammad Saim

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Overview

Analysis reveals mortality trends and racial disparities in bleeding disorders among U.S. adults, highlighting healthcare policy implications.

Key Points

  • To identify mortality trends linked to coagulation defects and associated demographic factors in the U.S. population from 1999 to 2023.
  • Analyzed CDC WONDER database for mortality data from 1999 to 2023
  • Focused on individuals aged ≥55 with coagulation defects as the primary cause of death
  • Employed Joinpoint Regression software to assess trends in age-adjusted mortality rates
  • Calculated annual percentage change using a weighted Bayesian Information Criterion model
  • 53,799 deaths reported among U.S. adults aged 55 and older from coagulation defects
  • Overall age-adjusted mortality rate was 2.9 per million with a significant decline over time
  • Male mortality exhibited a notable decline from 2014 to 2023, with females accounting for a higher percentage of total deaths
  • Racial disparities observed with significant decreases in mortality among White and Hispanic populations
  • South region had the highest mortality rate; West Virginia reported the highest AAMR at 4.4 per million.

Cite This Study

Tareen et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d907https://doi.org/10.1182/blood-2025-6638
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  1. 1Race-based disparities in hemorrhagic stroke mortality with underlying coagulopathies: A CDC-wonder analysis (1999–2020)2025
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  5. 5Trends and disparities in disseminated intravascular coagulation-related mortality among adults aged 25 and above in the U.S., 1999–2020: CDC WONDER insights2026