Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Establishment of a prognostic model for diffuse large B-cell lymphoma based on mitochondrial energy metabolism-related genes

View Full Paper
Ask AI
Bookmark
Share

Authors

YLYutang LiMHMengyuan He

Discussion

Loading...

Member takes

Overview

Prognostic model improves risk stratification in diffuse large B-cell lymphoma, suggesting immunotherapy targets.

Key Points

  • The aim was to develop a prognostic model for diffuse large B-cell lymphoma using mitochondrial metabolism-related genes.
  • Constructed a prognostic model based on mitochondrial metabolism-related genes.
  • Conducted consensus clustering to identify metabolic subtypes with differing outcomes.
  • Utilized LASSO-Cox regression to develop a seven-gene risk model.
  • The seven-gene risk model effectively stratified patients into high- and low-risk groups.
  • Low-risk patients exhibited significantly prolonged overall survival (P < 0.001).
  • High-risk groups showed lower immune scores and increased infiltration of immunosuppressive cells.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d68fhttps://doi.org/10.1182/blood-2025-7086
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A prognostic model for multiple myeloma based on lipid metabolism related genes.2025 · 1 citations
  2. 2Comprehensive analysis of mitochondrial metabolism–associated clusters and prognostic scoring model index construction in breast cancer2026
  3. 3Risk Model Based On Neutrophil-Related Genes Constructs to Assess Prognosis and Immune Landscape in Diffuse Large B-Cell Lymphoma2025
  4. 4Leveraging mitochondrial dynamics-related risk signatures to predict the prognosis and tumor microenvironment of lung adenocarcinoma2026
  5. 5Development and validation of mitochondrial metabolism-related genes in the prognostic and immunological characterization of clear cell renal cell carcinoma2025