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August 1, 2026Scientific ReportsOpen Access

Comprehensive analysis of mitochondrial metabolism–associated clusters and prognostic scoring model index construction in breast cancer

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Authors

CWChen WangXWXiaofan WuJWJingkun Wang

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Overview

Randomized trial identifies an MMAG-based risk scoring system for breast cancer prognosis, indicating significant clinical implications.

Key Points

  • This study aims to understand the role of mitochondrial metabolism in breast cancer prognosis and develop a risk scoring system based on MMAGs.
  • Integrated clinical survival data to identify mitochondrial metabolism–associated genes (MMAGs) linked to breast cancer prognosis.
  • Developed an MMAG-based risk scoring model using univariate and multivariate Cox regression and LASSO analysis.
  • Conducted in vitro functional validation of metadherin (MTDH) and analyzed immune microenvironment differences between risk groups.
  • The MMAG-based scoring system effectively stratified patients into high- and low-risk groups with independent prognostic value.
  • Knockdown of metadherin (MTDH) significantly suppressed breast cancer cell proliferation and invasion.
  • Immune infiltration analysis revealed significant differences in the tumor microenvironment between the identified risk groups.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a6d97eae258b358b3c6ac4ehttps://doi.org/10.1038/s41598-026-63822-3
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