Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Semantic features associated with outcome in patients treated with CAR-T therapy

View Full Paper
Ask AI
Bookmark
Share

Authors

JCJung Woo Choi

Discussion

Loading...

Member takes

Overview

Research reveals relationships between baseline PET/CT semantic features and treatment response, indicating potential prognostic value in patients with DLBCL.

Key Points

  • To evaluate the role of radiological semantic traits in treatment response to CAR-T therapy for DLBCL patients.
  • Systematically assessed five semantic characteristics on baseline PET/CT imaging
  • Measured treatment response as progression-free survival after one year
  • Used Cox-regression model to analyze relationship between semantic traits and treatment outcomes.
  • The side of the diaphragm correlates with adverse treatment outcomes (hazard ratio over 3.7)
  • Metabolic tumor volume remains significantly related to adverse outcomes (hazard ratio of 2.6)
  • Other semantic metrics did not show significant impact.

Cite This Study

Jung Woo Choi (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d694https://doi.org/10.1182/blood-2025-7077
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Predicting survival outcomes in CAR-t treated B-cell lymphoma by combining PET/CT imagingand clinical features2025
  2. 2Systematic review and meta−analysis of PET−based prognostic metrics in CAR−T treatment of DLBCL2026 · 2 citations
  3. 3Predicting survival, neurotoxicity and response in B-Cell lymphoma patients treated with CAR-T therapy using an imaging features-based model2024
  4. 4Deep learning-based image analysis of pretreatment FDG-PET/CT predicts CAR-T cell treatment outcome at month-12 for patients with Relapsed/Refractory large B-cell lymphomas2025 · 1 citations
  5. 5Prognostic significance of fludeoxyglucose positron emission tomography delta radiomics following bridging therapy in patients with large B-cell lymphoma undergoing CAR T-cell therapy2024 · 4 citations