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December 8, 2025Blood

Immune dysregulation in newly diagnosed DLBCL: From clinical observations to molecular mechanisms

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Authors

YPYuanyuan Pan

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Overview

This analysis demonstrates associations of immune dysregulation and clinical features with infection risk in DLBCL, indicating the need for composite biomarkers.

Key Points

  • This study aims to analyze the relationship between immune dysregulation and clinical features in newly diagnosed DLBCL patients, focusing on infection risk and treatment response.
  • Retrospective enrollment of sixty-six newly diagnosed DLBCL patients.
  • Evaluation of lymphocyte subset distribution and maturation profiles using flow cytometry.
  • Logistic regression analysis to determine indicators of infection risk.
  • ROC analysis for assessing the prognostic value of immune markers.
  • Patients with B-symptoms showed distinct differences in T cell subsets compared to A-symptomatic patients.
  • Infected patients had higher levels of specific T cell populations than uninfected patients.
  • ROC analysis yielded an AUC of 0.753 for the combined markers, highlighting their potential as biomarkers for prognosis.

Cite This Study

Yuanyuan Pan (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d69bhttps://doi.org/10.1182/blood-2025-7085
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