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December 8, 2025BloodOpen Access

The role of ENO1 and chidamide in PTCL-NOS

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Authors

XGXuejiao GuZLZhenyu LiFZFeng Zhu

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Overview

Results indicate chidamide enhances apoptosis and inhibits cell cycle in PTCL-NOS via ENO1 knockdown, suggesting therapeutic potential.

Key Points

  • This research aims to explore the effects of ENO1 and chidamide in PTCL-NOS.
  • Examined ENO1 expression using RT-qPCR in cell lines and primary tumor samples.
  • Conducted CCK8 and colony formation assays to assess cell proliferation.
  • Analyzed cell migration through Transwell assays and apoptosis via flow cytometry.
  • Measured glucose uptake, lactate production, and total iron content using specific assay kits.
  • Utilized a mouse tumor model to study tumor behavior in vivo.
  • ENO1 was found to be upregulated in PTCL-NOS tissues and linked to lymph node metastasis.
  • Knockdown of ENO1 activated AMPK and promoted ferroptosis and autophagy.
  • Chidamide combined with ENO1 knockdown increased apoptosis and cell cycle arrest in PTCL-NOS cells.

Cite This Study

Gu et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d69dhttps://doi.org/10.1182/blood-2025-7081
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ENO1 inhibition synergizes with chidamide to induce ferroptosis in PTCL-NOS through metabolic remodeling2026
  2. 2ENO1 promotes Acute Myeloid Leukemia progression through SCD1-mediated lipid metabolism reprogramming2025
  3. 3Targeting ENO1 reprograms macrophage polarization to trigger antitumor immunity and improves the therapeutic effect of radiotherapy2026 · 7 citations
  4. 4Exploring the Role of ENO1 in Regulating Cell Proliferation and Cell Cycle in Hepatocellular Carcinoma: Insights from Proteomic Analysis2024
  5. 5Interference with ENO2 promotes ferroptosis and inhibits glycolysis in clear cell renal cell carcinoma by regulating Hippo‑YAP1 signaling2024 · 7 citations