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December 8, 2025ChemistrySelect

Antimicrobial Potential of Novel Quinazolin‐2,4‐dione Derivatives Bearing One and/or Two Amide Moieties: In Vitro Evaluation, Molecular Docking, and Semiempirical Calculations

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Authors

AAAboubakr H. AbdelmonsefEAEsam AbdallaHTHussain Temairk

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Overview

In Vitro evaluation finds quinazolin‐2,4‐dione derivatives effective against Gram-positive bacteria, suggesting potential as new antimicrobial agents.

Key Points

  • This research aims to evaluate the antimicrobial potential of novel quinazolin‐2,4‐dione derivatives.
  • Synthesis of quinazolin‐2,4‐dione derivatives with one or two amide moieties
  • Biological evaluation of antimicrobial activity against specific microbial strains
  • Molecular docking studies to assess binding energies and interactions
  • Semiempirical calculations for evaluating structural confirmation
  • Compounds 2b, 2c, and 4c show the most potent antimicrobial activity
  • Molecular docking indicates low binding energies compared to reference drugs
  • Favorable intermolecular interactions with target enzyme active sites were identified

Cite This Study

Abdelmonsef et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6a3https://doi.org/10.1002/slct.202504022
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