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December 8, 2025Blood

Clinical characteristics and prognostic factors in myeloid blast-Phase chronic myeloid leukemia

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Authors

HZHuifang ZhaoYZYingling ZuYZYanli Zhang

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Overview

Retrospective analysis shows poor prognosis and specific prognostic factors in chronic myeloid leukemia, highlighting treatment challenges.

Key Points

  • To identify clinical characteristics and prognostic factors in myeloid blast-phase chronic myeloid leukemia (MBP-CML).
  • Retrospective review of clinical records of 141 MBP-CML patients.
  • Data collection on demographics, disease characteristics, treatment response, and survival outcomes.
  • Cox proportional hazards regression models for prognostic factor analysis.
  • 5-year overall survival rate for MBP-CML patients is only 15%.
  • 78.7% had prior exposure to tyrosine kinase inhibitors (TKIs).
  • 18.4% experienced extramedullary blast crisis, with 5% isolated EMBC.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6bchttps://doi.org/10.1182/blood-2025-7287
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Also Consider

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  1. 1Management and outcome of patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era – analysis of the European LeukemiaNet Blast Phase Registry2024 · 27 citations
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  3. 3Phase II study of clia (cladribine, idarubicin, cytarabine) plus tyrosine kinase inhibitor (TKI) in patients with chronic myeloid leukemia in myeloid blast Phase2025
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  5. 5Chronic Myeloid Leukemia Presenting with Megakaryocytic Blast Crisis: a Case Report with a Favorable Outcome2024