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October 12, 2025Leukemia & lymphoma/Leukemia and lymphoma

Clinical outcomes of allogeneic cell transplantation for patients with chronic myeloid leukemia

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Authors

BMBenjamin J. McCormickAFAngelica FindleyKDKendall Diebold

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Overview

Retrospective analysis shows overall survival rates in leukemia types after transplantation, indicating disease biology influences outcomes.

Key Points

  • Median overall survival was 50 months in myeloid blast phase, indicating varied outcomes based on leukemia type.
  • Patients in transformed myeloid blast phase had worse relapse rates compared to those in lymphoid blast phase.
  • Allo-HCT demonstrated efficacy in treating TKI-resistant chronic myeloid leukemia with varied survival based on cytogenetic features.
  • Post-transplant maintenance with TKI did not significantly improve relapse or survival rates in this cohort.

Cite This Study

McCormick et al. (2025) studied this question.

synapsesocial.com/papers/68eb8fe250220ac955d94c2ehttps://doi.org/10.1080/10428194.2025.2564766
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long-term outcomes of CML patients undergoing hematopoietic stem cell transplantation in the era of tyrosine kinase inhibitors2025
  2. 2Allogeneic hematopoietic cell transplantation for acute myeloid leukemia with <i>BCR::ABL1</i> fusion2024 · 2 citations
  3. 3Stem cell allografting for chronic Myeloid leukemia in the tyrosine kinase era – forgotten but not gone2024 · 3 citations
  4. 4Myeloablative and Reduced Intensity Allogeneic Transplant in Patients with Myeloproliferative Neoplasms.2025
  5. 5Management and outcome of patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era – analysis of the European LeukemiaNet Blast Phase Registry2024 · 27 citations