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December 8, 2025BloodOpen Access

Immune restoration in long-term myeloma survival revealed by single-cell RNA-sequencing

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Authors

KPKirthi PulakantiVersiti Blood Center of WisconsinJMJosiah MurrayMedical College of WisconsinRNRavi NarraMedical College of Wisconsin

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Implication

Using single-cell RNA sequencing, immune restoration correlates with disease control in long-term multiple myeloma survival patients, highlighting cell communication mechanisms.

Key Points

  • This research aims to uncover the immune mechanisms underlying long-term survival in multiple myeloma patients using single-cell RNA sequencing.
  • Bone marrow samples from multiple myeloma patients were analyzed using single-cell RNA sequencing.
  • Pseudobulk differential expression and immune pathway enrichment analyses were conducted.
  • Cell-cell communication was assessed with the CellChat tool to analyze immune interactions.
  • LTS patients maintained transcriptionally malignant plasma cells with features similar to newly diagnosed multiple myeloma.
  • Immune cell interactions were significantly increased in LTS patients compared to other stages.
  • LTS exhibited a robust immune bone marrow microenvironment, indicating functional restoration and enhanced immune competence.

Cite This Study

Pulakanti et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6c4https://doi.org/10.1182/blood-2025-5716
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long-term survival in multiple myeloma is associated with a distinct immunological profile, which includes proliferative cytotoxic T-cell clones and a favourable Treg/Th17 balance2013 · 136 citations
  2. 2Multi-omics reveals immune features in immune and non-immune cells, an IFN-γ/IFN-α-B2M positive feedback loop, and targeted metabolic therapy in multiple myeloma2025
  3. 3Abstract 6881: Investigating the role of post-transplant bone marrow immune dysregulation in multiple myeloma2024
  4. 4Longitudinal profiling of tumor and immune compartments uncovers patterns of dysregulation and associations with response in multiple myeloma2025
  5. 5Relapse Despite <scp>MRD</scp> Negativity in Multiple Myeloma: Toward Integrated Risk Prediction2026 · 1 citations