What type of study is this?

This is a In Vitro Study study.

What question did this study set out to answer?

This research investigates the effects of menin-inhibition on graft-versus-leukemia (GVL) responses following allogeneic hematopoietic cell transplantation (allo-HCT) for AML.

December 8, 2025Blood

Post allo-HCT menin-inhibition enhances graft-versus-leukemia effects by endogenous retrovirus induction in AML and T-cell activation

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Authors

LSLennard Frederik Schwöbel ASA. Stell MPMarco Punta

Discussion

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Overview

Menin-inhibition improves T-cell activation and cytotoxicity in AML while enhancing GVL effects post allo-HCT, indicating clinical potential.

Key Points

This research investigates the effects of menin-inhibition on graft-versus-leukemia (GVL) responses following allogeneic hematopoietic cell transplantation (allo-HCT) for AML.
Examined the impact of menin-inhibitors on KMT2A-rearranged and NPM1-mutated AML cells in vitro and in vivo.
Analyzed MHC-II and CIITA expression, T-cell activation markers, and performed transcriptomic profiling and flow cytometry.
Utilized murine allograft models and human xenograft models to assess GVL effects and histological outcomes.
Menin-inhibition increased MHC-II expression, enhancing T-cell-mediated elimination of AML cells post allo-HCT.
Increased T-cell activation markers such as IFN-γ, perforin, and granzyme A were observed following treatment.
No rise in acute graft-versus-host-disease (GVHD) scores was noted in treated subjects.

Cite This Study

Schwöbel et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6d2 https://doi.org/10.1182/blood-2025-5862

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December 8, 2025Blood

Post allo-HCT menin-inhibition enhances graft-versus-leukemia effects by endogenous retrovirus induction in AML and T-cell activation

View Full Paper

Ask AI

Bookmark

Authors

LSLennard Frederik Schwöbel ASA. Stell MPMarco Punta

Discussion

Member takes

Overview

Menin-inhibition improves T-cell activation and cytotoxicity in AML while enhancing GVL effects post allo-HCT, indicating clinical potential.

Key Points

This research investigates the effects of menin-inhibition on graft-versus-leukemia (GVL) responses following allogeneic hematopoietic cell transplantation (allo-HCT) for AML.
Examined the impact of menin-inhibitors on KMT2A-rearranged and NPM1-mutated AML cells in vitro and in vivo.
Analyzed MHC-II and CIITA expression, T-cell activation markers, and performed transcriptomic profiling and flow cytometry.
Utilized murine allograft models and human xenograft models to assess GVL effects and histological outcomes.
Menin-inhibition increased MHC-II expression, enhancing T-cell-mediated elimination of AML cells post allo-HCT.
Increased T-cell activation markers such as IFN-γ, perforin, and granzyme A were observed following treatment.
No rise in acute graft-versus-host-disease (GVHD) scores was noted in treated subjects.

Cite This Study

Schwöbel et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6d2 https://doi.org/10.1182/blood-2025-5862

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