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December 8, 2025Blood

Menin-inhibition boosts CAR-T cell therapy against NPM1 mutated and KMT2A-rearranged acute myeloid leukemia

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Authors

JHJan HabermannCLCatharina LahrmannMDMichael Delacher

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Overview

Findings reveal menin inhibition boosts CD11b expression in NPM1 and KMT2A leukemias, enhancing CAR-T effectiveness.

Key Points

  • This research explores the effects of menin inhibitors on CAR-T cell therapy for acute myeloid leukemia (AML).
  • Examined menin inhibitors in KMT2A-rearranged and NPM1-mutated AML cells.
  • Utilized RNA sequencing and flow cytometry to assess gene expression and differentiation markers.
  • Evaluated combined effects of menin inhibitors and CAR-T cell treatment in vitro and in xenograft models.
  • Menin inhibitors increased CD11b expression and enhanced efficacy of CLEC12A-directed CAR-T therapy.
  • Combination therapy outperformed single treatments in multiple donor samples.
  • In vivo treatment showed significant reduction of leukemic cells in xenograft models.

Cite This Study

Habermann et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d75fhttps://doi.org/10.1182/blood-2025-866
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Post allo-HCT menin-inhibition enhances graft-versus-leukemia effects by endogenous retrovirus induction in AML and T-cell activation2025
  2. 2Therapeutic Implications of Menin Inhibitors in the Treatment of Acute Leukemia: A Critical Review2025 · 7 citations
  3. 3The role of menin inhibitors in acute myeloid leukemia2025 · 2 citations
  4. 4Menin Inhibition in Acute Myeloid MLL Rearranged Leukemias: A New Target for Precision Care2026 · 3 citations
  5. 5The promise of menin inhibitors: from approval to triplet regimens2025 · 9 citations