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December 8, 2025Blood

Healthcare inequities in Latin America outweigh the benefits of pediatric regimens in adult acute lymphoblastic leukemia

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Authors

WSWellington F SilvaMEMarcela EspinozaEAEdgar Zapata Avila

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Overview

Retrospective cohort analysis reveals socioeconomic factors influence survival in adults with acute lymphoblastic leukemia, indicating disparities in treatment across public and private healthcare in

Key Points

  • This research analyzes the impact of healthcare inequities on survival outcomes in adult patients with acute lymphoblastic leukemia in Latin America.
  • Retrospective multi-site cohort study
  • Patients aged 15 years and above with newly diagnosed acute lymphoblastic leukemia
  • Data collected from 7 centers in Brazil and 13 centers in Chile
  • Primary outcomes included overall survival and event-free survival
  • Comparison of treatment regimens in public vs. private health systems
  • Median age of patients was 37.5 years, with a significant portion being male (52.6%)
  • Four-year overall survival rates were significantly higher in private centers (51.6%) compared to public centers (34.9%)
  • Treatment with dasatinib improved outcomes for Ph+ patients, while no benefit of pediatric regimens was noted overall
  • Allogeneic stem-cell transplant rates were greater in private centers (59.1%) than public ones (33.1%)

Cite This Study

Silva et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6f4https://doi.org/10.1182/blood-2025-288
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Real-world outcomes and disparities of ph+ ALL in a Latino population2025
  2. 2Clinical characteristics, prognosis, and achievement of transplant in adolescents and adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia in Argentina2026
  3. 3Global survival of pediatric patients with acute lymphoblastic leukemia from a Latin American Hospital2024
  4. 4Effect of Adults and Pediatric-inspired Schemes on Negative Measurable Residual Disease and Overall Survival in Adults with Acute Lymphoblastic Leukemia: A Retrospective Analysis from the Hematology Department at Hospital Regional de Alta Especialidad de Ixtapaluca, Mexico2025
  5. 5Clinical Outcome and Prognostic Factors in Childhood Acute Lymphoblastic Leukemia—A Retrospective Cohort Study of Patients from Southern Mexico2026