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September 8, 2026Hematology Transfusion and Cell TherapyOpen Access

Clinical characteristics, prognosis, and achievement of transplant in adolescents and adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia in Argentina

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Authors

MCMaría Manuela ClavijoJRJuan Ignacio RuizLFLuciana Ferrari

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Overview

Retrospective cohort study reveals that public hospital care impairs stem cell transplant access and survival in acute lymphoblastic leukemia, highlighting profound healthcare disparities.

Key Points

  • To characterize adolescents and adults with Philadelphia chromosome-negative acute lymphoblastic leukemia in Argentina and identify factors influencing overall survival and access to first-line allogeneic stem cell transplantation.
  • Conducted a multicenter retrospective cohort study across 15 centers in Argentina among 305 adolescent and adult patients diagnosed between 2014 and 2022.
  • Performed univariate, multivariate, and competing risk survival analyses to determine independent predictors of overall survival and stem cell transplant achievement.
  • Median overall survival was 42 months, with independently worse outcomes associated with public institution care (HR 1.61), central nervous system involvement (HR 1.56), high-risk chemotherapy regimens (HR 1.89), and older age (HR 1.02).
  • Among 199 patients indicated and eligible for allogeneic stem cell transplantation, only 20.1% received one, with public hospital treatment reducing transplant likelihood by 65% (p = 0.013; subdistribution HR 0.28).

Cite This Study

Clavijo et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd7e758e84d0ff5b46f92https://doi.org/10.1016/j.htct.2026.106530
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