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December 8, 2025Blood

Exploring the disease impact of plasma metabolites on marginal zone lymphoma based on mendelian randomization

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Authors

KLKang Lu

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Overview

Mendelian randomization identifies key plasma metabolites and genes influencing marginal zone lymphoma progression, suggesting novel targets for treatment.

Key Points

  • The study aims to investigate the relationship between plasma metabolites and marginal zone lymphoma.
  • Utilized two-sample Mendelian Randomization (MR) for analysis.
  • Derived exposure data from genome-wide association studies of plasma metabolites.
  • Applied inverse variance weighted, MR-Egger, and weighted median methods for primary analysis.
  • Conducted heterogeneity and pleiotropy analyses, and sensitivity analyses.
  • Identified instrumental variables for statistical significance and performed gene annotation.
  • Identified three protective plasma metabolites and one risk metabolite for MZL.
  • Sensitivity analysis confirmed robustness without significant heterogeneity or pleiotropy.
  • Found statistical significance in 71 patient genes related to the disease.
  • Key metabolic pathways involved include propanoate metabolism and ABC transporters.
  • Differential expression of eight key genes was noted between MZL patients and controls.

Cite This Study

Kang Lu (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d71ahttps://doi.org/10.1182/blood-2025-7122
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  5. 5Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study2025