Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 2025Open MedicineOpen Access

Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study

View Full Paper
Ask AI
Bookmark
Share

Authors

XHXinhang HuFYFenglei YuMPMuyun Peng

Discussion

Loading...

Member takes

Overview

Bidirectional Mendelian randomization study reveals causal cytokine links in marginal zone lymphoma, highlighting potential diagnostic biomarkers and therapeutic targets.

Key Points

  • Investigate potential bidirectional causal associations between 41 circulating inflammatory cytokines and marginal zone lymphoma.
  • Conducted a two-sample bidirectional Mendelian randomization study using genetic variant summary data from two large-scale genome-wide association studies.
  • Applied inverse variance weighting as the primary analytical method alongside sensitivity analyses (MR-Egger, weighted median, simple model, and weighted model) to assess estimate robustness.
  • Genetically predicted elevations in MIG (OR = 1.57, p = 0.035) and IL-10 (OR = 1.69, p = 0.021) were associated with higher risk of marginal zone lymphoma, while B-NGF was protective (OR = 0.46, p = 0.027).
  • Reverse Mendelian randomization revealed that marginal zone lymphoma causally associates with decreased circulating IFN-γ levels (OR = 0.97, p = 0.015).

Cite This Study

Hu et al. (2025) studied this question.

synapsesocial.com/papers/6a7d655258b935a3e446dee0https://doi.org/10.1515/med-2025-1171
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dissecting causal links between gut microbiota, inflammatory cytokines, and DLBCL: a Mendelian randomization study2024 · 30 citations
  2. 2Mediating Effects of Plasma Metabolites in Inflammatory Protein-Lymphoma Causality: A Mendelian Randomization Study2025
  3. 3Associations of the circulating levels of cytokines with the risk of myeloproliferative neoplasms: a bidirectional mendelian-randomization study2024 · 5 citations
  4. 4Investigating the causal linkages between circulating inflammatory proteins and breast cancer risk and prognosis: Insights from a two-sample Mendelian randomization analysis2026
  5. 5Exploration of the causal associations between circulating inflammatory proteins, immune cells, and neuromyelitis optica spectrum disorder: a bidirectional Mendelian randomization study and mediation analysis2024 · 15 citations