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December 8, 2025Blood

Multiple myeloma with ≥1% circulating plasma cells in peripheral blood has a poor prognosis

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Authors

KMKosuke MikiKWKentaro WakasaTSTsuyoshi Sato

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Overview

Retrospective analysis shows circulating plasma cells ≥1% indicate worse prognosis in newly diagnosed multiple myeloma, suggesting revised cutoff criteria.

Key Points

  • This study aims to clarify the prognostic significance of low-level circulating plasma cells in multiple myeloma patients.
  • Retrospective analysis of 854 newly diagnosed multiple myeloma patients from the North Japan Hematology Study Group database.
  • Patients were categorized based on the percentage of circulating plasma cells in peripheral blood.
  • Survival outcomes were compared between patients with ≥1% and <1% circulating plasma cells.
  • Patients with circulating plasma cells ≥1% had a median overall survival of 37.9 months compared to 98.7 months for those with <1%.
  • Multivariate analysis identified ≥1% circulating plasma cells as an independent factor for inferior overall survival.
  • Upfront autologous stem cell transplantation improved outcomes for patients with ≥1% circulating plasma cells.

Cite This Study

Miki et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d7cdhttps://doi.org/10.1182/blood-2025-2205
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Quantification of circulating plasma cells at diagnosis can identify functional high risk multiple myeloma patients2025
  2. 2Monoclonal and polyclonal circulating plasma cells (CPCs) are linked to disease spread in multiple myeloma2025
  3. 3P18 | MONOCLONAL AND POLYCLONAL CIRCULATING PLASMA CELLS ARE ASSOCIATED WITH DISEASE DISSEMINATION IN MULTIPLE MYELOMA2026
  4. 4A Clinical Perspective on Plasma Cell Leukemia: A Single-Center Experience2024 · 5 citations
  5. 5Prognostic Implications of Circulating Plasma Cell Percentage in Multiple Myeloma and Primary Plasma Cell Leukemia Defined by New Criteria2024 · 2 citations