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This research aims to explore the correlation between circulating plasma cells and tumor dissemination in multiple myeloma.

December 8, 2025BloodOpen Access

Monoclonal and polyclonal circulating plasma cells (CPCs) are linked to disease spread in multiple myeloma

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Observational study links circulating plasma cells to tumor dissemination in multiple myeloma, suggesting implications for risk assessment.

This research aims to explore the correlation between circulating plasma cells and tumor dissemination in multiple myeloma.
Analyzed 140 newly diagnosed multiple myeloma patients.
Collected bone marrow aspirates and peripheral blood samples at diagnosis.
Assessed tumor dissemination using diffusion-weighted magnetic resonance imaging and imaging characteristics.
80% of patients had detectable circulating plasma cells (CPCs) at diagnosis.
Patients with CPCs exhibited a higher genomic risk profile and unfavorable biochemical parameters.
The presence of CPCs correlated with worse imaging profiles, including increased osteolytic lesions.

Talarico et al. (2025) studied this question.

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Observational study links circulating plasma cells to tumor dissemination in multiple myeloma, suggesting implications for risk assessment.