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December 8, 2025BloodOpen Access

Clinical course, predictors of development, and therapeutic response in multiple myeloma with central nervous system involvement

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Authors

YLYi LinMBMoritz BinderMGMorie A. Gertz

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Overview

Retrospective analysis reveals CNS involvement reduces survival in multiple myeloma, suggesting immune therapies may improve outcomes.

Key Points

  • To examine predictors of central nervous system involvement and the outcomes of multiple myeloma patients with CNS complications.
  • Conducted a retrospective analysis of multiple myeloma patients with CNS involvement between 2000 and 2023.
  • Identified clinical characteristics and treatment responses of patients with cerebrospinal fluid involvement.
  • Performed univariate analysis comparing EMD patients with CNS involvement to those without.
  • Identified 22 CNS-MM patients from a total of 305 EMD cases, with median overall survival of 6 months for CNS-MM.
  • Patients with CNS-MM had high-risk cytogenetics in 73% of cases compared to 40% in EMD patients without CNS involvement.
  • 32% of CNS-MM patients showed overall response to treatment as compared to 48% in EMD patients without CNS-MM.

Cite This Study

Lin et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d7d9https://doi.org/10.1182/blood-2025-2225
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical Course, Risk Factors, and Therapeutic Response in Multiple Myeloma with Central Nervous System Involvement2026 · 1 citations
  2. 2Clinical Characteristics, Treatment Patterns, and Prognosis of Central Nervous System Involvement in Multiple Myeloma: A Multicenter Retrospective Study From China2026
  3. 3Central nervous system multiple myeloma: A real‐world multi‐institutional study of the Greek Myeloma Study Group2024 · 22 citations
  4. 4Clinical characteristics and prognosis of central nervous system involvement in multiple myeloma: a multicenter retrospective analysis from China2025
  5. 5CNS Involvement of Multiple Myeloma—A Case Series and Narrative Literature Review2026