Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 27, 2026Blood AdvancesOpen Access

Clinical Course, Risk Factors, and Therapeutic Response in Multiple Myeloma with Central Nervous System Involvement

View Full Paper
Ask AI
Bookmark
Share

Authors

AXAlexander XiaoSZSaurabh ZanwarYLYi Lin

Discussion

Loading...

Member takes

Overview

Retrospective analysis identifies risk factors and treatment outcomes for CNS involvement in multiple myeloma, suggesting effective therapies.

Key Points

  • This analysis aims to explore the clinical course and therapeutic outcomes of multiple myeloma patients with central nervous system involvement.
  • Retrospective analysis of 304 multiple myeloma patients with pathology-confirmed extramedullary disease treated from January 2000 to December 2023.
  • CNS-MM defined by parenchymal or leptomeningeal involvement, with predictors evaluated among patients with EMD.
  • Outcomes analyzed based on treatments, including CAR-T cell therapy and bispecific antibodies.
  • 20 patients (6.5%) had CNS-MM; median onset was 19.2 months post-MM diagnosis, with 15% at diagnosis.
  • CNS-MM associated with high-risk cytogenetics (OR 3.7) and additional visceral EMD (OR 4.6).
  • Median overall survival was 19.2 months with CAR-T or bispecific therapies versus 1.2 months without immune effector therapies.

Cite This Study

Xiao et al. (2026) studied this question.

synapsesocial.com/papers/6a3f6871aea7db3c1953f8cahttps://doi.org/10.1182/bloodadvances.2026020668
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical course, predictors of development, and therapeutic response in multiple myeloma with central nervous system involvement2025
  2. 2Clinical Characteristics, Treatment Patterns, and Prognosis of Central Nervous System Involvement in Multiple Myeloma: A Multicenter Retrospective Study From China2026
  3. 3Central nervous system multiple myeloma: A real‐world multi‐institutional study of the Greek Myeloma Study Group2024 · 22 citations
  4. 4Clinical characteristics and prognosis of central nervous system involvement in multiple myeloma: a multicenter retrospective analysis from China2025
  5. 5Characteristics, treatment regimens, and outcomes of patients with true extramedullary multiple myeloma: a real-world monocentric analysis2026