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December 8, 2025BloodOpen Access

Clinical, genetic, and pathologic differences across race, ethnicity, and sex in patients with MDS and precursor conditions from the national MDS natural history study

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Authors

CCChristelle ColinLZLing ZhangGAGregory A. Abel

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Overview

Analysis reveals differences in somatic mutations and progression-free survival in MDS by race, ethnicity, and sex.

Key Points

  • This research aims to define the epidemiology and variation in myelodysplastic syndromes across demographics.
  • Participants were enrolled from 102 US sites undergoing evaluation for suspected MDS.
  • Bone marrow assessment and centralized histopathology review were conducted.
  • DNA sequencing was performed to identify pathogenic variants in 53 genes.
  • Statistical analyses, including logistic regression and Cox models, were utilized to assess associations.
  • 58% of 2,021 participants were diagnosed with MDS or precursor conditions.
  • Common mutations included DNMT3A and advanced disease metrics among Black participants.
  • Progression-free survival varied by sex and ethnicity, revealing biological disparities in outcomes.

Cite This Study

Colin et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d831https://doi.org/10.1182/blood-2025-3845
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical, Genetic, and Pathologic Variability in Myelodysplastic Syndromes and Precursor Conditions Across Race, Ethnicity, and Sex2026
  2. 2A novel approach to defining progression in MDS and precursor myeloid conditions in The MDS Natural History Study2026 · 4 citations
  3. 3Myelodysplastic/myeloproliferative overlap neoplasms: Clinicopathological features, treatment strategies, and outcomes — a UK multicentre cohort Study2025
  4. 4Epidemiologic insights into early-onset myelodysplastic syndrome: A longitudinal SEER analysis (2000-2022)2025
  5. 5Molecular subclusters across the continuum of myelodysplastic neoplasms and acute myeloid leukaemia define distinct clinical entities2025