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December 8, 2025BloodOpen Access

Epidemiologic insights into early-onset myelodysplastic syndrome: A longitudinal SEER analysis (2000-2022)

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Authors

JAJowan Al‐NusairKSKatherine M. Steele

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Overview

Retrospective analysis reveals stable incidence and survival patterns in early-onset MDS, suggesting environmental influences.

Key Points

  • To investigate the epidemiological patterns and survival outcomes of early-onset myelodysplastic syndrome (MDS).
  • Retrospective cohort analysis of SEER registry data from 2000 to 2022
  • Focused on adults aged 20-49 years with early-onset MDS
  • Calculated age-adjusted incidence rates per 100,000 person-years
  • Analyzed demographic characteristics and relative survival estimates
  • Identified 2,856 early-onset MDS cases yielding an incidence rate of 0.4 per 100,000
  • Stable annual incidence rates between 2000 and 2022, ranging from 0.3 to 0.4
  • Females had better survival: 12-month relative survival of 87.6% vs. 79.9% for males
  • Younger patients had significantly higher 5-year relative survival compared to those aged 50 and over (59.9% vs. 40.3%)

Cite This Study

Al‐Nusair et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dc03https://doi.org/10.1182/blood-2025-7374
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