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December 8, 2025BloodOpen Access

Trends and disparities in myelodysplastic Syndrome–Associated mortality in the u.S. from 1999 to 2020: A population-based study using the CDC wonder database

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Authors

AIAyman Irshad

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Overview

Population-based analysis shows rising MDS mortality trends, indicating disparities in healthcare access by race and ethnicity.

Key Points

  • This analysis aimed to evaluate trends and disparities in mortality associated with myelodysplastic syndromes (MDS) in the US from 1999 to 2020.
  • Retrospective analysis using CDC WONDER database
  • Included adults ≥25 years with MDS as a cause of death
  • Calculated age-adjusted mortality rates (AAMRs) annually
  • Evaluated temporal trends with Joinpoint regression
  • Performed subgroup analyses by sex, race/ethnicity, and geography.
  • Age-adjusted mortality rate for MDS increased then declined over the study period
  • Higher rates observed in males and Non-Hispanic Whites
  • Geographic disparities in mortality across US regions
  • Small metropolitan areas reported highest AAMR
  • Suggests ongoing inequities in healthcare access and treatment availability.

Cite This Study

Ayman Irshad (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e53dhttps://doi.org/10.1182/blood-2025-2655
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Temporal trends and demographic disparities in myelodysplastic syndrome-associated mortality in Acute Myeloid Leukemia patients in the United States: A population-based analysis (1999–2023)2025
  2. 2Two decades of infectious mortality in Myelodysplastic Syndromes: An analysis from the CDC wonder database2025
  3. 3Trends in Acute Myeloid Leukemia mortality among patients with myelodysplastic syndrome in the United States (1999–2024): A CDC wonder database analysis2025
  4. 4Blood and filters: The intersection of myelodysplastic syndrome and renal failure in u.S. mortality trends (1999–2023)2025
  5. 5Two-decade trends and future projections of heart failure mortality in Myelodysplastic Syndromes: A nationwide population-based study (1999–2030)2025