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December 8, 2025BloodOpen Access

Two-decade trends and future projections of heart failure mortality in Myelodysplastic Syndromes: A nationwide population-based study (1999–2030)

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Authors

ADAllah DadHAHafsa AhmedMKMadhurendra Kumar

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Overview

Nationwide analysis finds heart failure mortality rates rising for myelodysplastic syndromes, suggesting socio-demographic disparities persist.

Key Points

  • To investigate trends and projections of heart failure mortality in patients with myelodysplastic syndromes over two decades.
  • Retrospective population-based analysis using the CDC WONDER database
  • Age-adjusted mortality rates calculated
  • Temporal trends assessed via Joinpoint regression
  • ARIMA models fitted with Box-Cox transformation for future projections
  • Subgroup analyses stratified by sex, race, and region
  • 4,947 heart failure-related deaths among individuals with MDS from 1999-2023
  • Age-adjusted mortality rate rose from 2.5 per million in 1999 to 2.7 per million in 2023
  • Higher mortality rates observed in males compared to females
  • Racial disparities noted, with white individuals experiencing an increase in mortality rates
  • Forecasts project continued rise in mortality rates through 2030

Cite This Study

Dad et al. (2025) studied this question.

synapsesocial.com/papers/693624d74fa91c937236d14dhttps://doi.org/10.1182/blood-2025-4433
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