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December 8, 2025BloodOpen Access

Longitudinal trends (1999–2023) and forecasted mortality (2024–2030) in sepsis-associated mortality among patients with Myelodysplastic Syndromes in the United States.

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Authors

HTHaseeb TareenADAllah DadSBSakshi Bai

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Overview

Analysis shows increasing sepsis-related mortality in myelodysplastic syndromes patients, highlighting demographic disparities and future forecasts.

Key Points

  • To analyze trends in sepsis-related mortality among patients with myelodysplastic syndromes and forecast future rates.
  • Analyzed CDC WONDER data from 1999 to 2023 for MDS and sepsis deaths.
  • Calculated age-adjusted mortality rates and trends using Joinpoint regression.
  • Developed ARIMA models to forecast mortality rates through 2030.
  • 20,187 sepsis-related deaths observed in MDS patients from 1999 to 2023.
  • Overall age-adjusted mortality rate decreased from 18.2 per million in 1999 to 16.7 in 2023.
  • Males showed a higher mortality rate compared to females, with noticeable fluctuations.

Cite This Study

Tareen et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e53chttps://doi.org/10.1182/blood-2025-2658
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Also Consider

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  1. 1Trends and disparities in myelodysplastic Syndrome–Associated mortality in the u.S. from 1999 to 2020: A population-based study using the CDC wonder database2025
  2. 2Two decades of infectious mortality in Myelodysplastic Syndromes: An analysis from the CDC wonder database2025
  3. 3Temporal trends and demographic disparities in myelodysplastic syndrome-associated mortality in Acute Myeloid Leukemia patients in the United States: A population-based analysis (1999–2023)2025
  4. 4Two-decade trends and future projections of heart failure mortality in Myelodysplastic Syndromes: A nationwide population-based study (1999–2030)2025
  5. 5Blood and filters: The intersection of myelodysplastic syndrome and renal failure in u.S. mortality trends (1999–2023)2025