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December 8, 2025Blood

Molecular subclusters across the continuum of myelodysplastic neoplasms and acute myeloid leukaemia define distinct clinical entities

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Authors

SHSuzan van Hoppe

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Overview

Analysis identifies distinct molecular subgroups in myelodysplastic neoplasms and acute myeloid leukaemia, suggesting diverse treatment responses.

Key Points

  • This research aims to classify patients with myelodysplastic neoplasms and acute myeloid leukaemia using molecular subtypes for better treatment decisions.
  • Clustering techniques were applied to targeted sequencing data of a population cohort.
  • A total of 1085 patients diagnosed with AML and MDS were analyzed.
  • 69 genetic features were examined to identify subgroups using Bernoulli distributions.
  • Survival and treatment responses were correlated with identified genetic clusters.
  • Eight molecular clusters were identified, varying in characteristics across AML and MDS cases.
  • The SF3B1 cluster demonstrated the best overall survival, while TP53 showed the worst.
  • Genomic profiles were similar within clusters, regardless of AML or MDS classification.

Cite This Study

Suzan van Hoppe (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d855https://doi.org/10.1182/blood-2025-3869
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Deciphering clonal progression in MDS via longitudinal sequencing2025
  2. 2Which molecular patterns of high-risk myeloid malignancies are concordantly identified using two machine learning algorithms?2025
  3. 3Longitudinal genomic and cytogenetic dynamics in myelodysplastic syndromes (MDS): Insights into clonal evolution and disease progression2025
  4. 4MDS/AML and AML with myelodysplasia-related gene mutations: clinical and molecular similarities.2026
  5. 5Abstract 6206: Molecular stratification of AML: Integrative genomic and immune profiling points to high risk subgroup and targetable molecular drivers2024 · 1 citations