Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
December 8, 2025BloodOpen Access

Deciphering clonal progression in MDS via longitudinal sequencing

View Full Paper
Ask AI
Bookmark
Share

Authors

VDVikramjit DhillonDPDakshin PadmanabhanSBSuresh Kumar Balasubramanian

Discussion

Loading...

Member takes

Overview

Longitudinal sequencing identifies molecular cluster shifts in MDS patients, suggesting implications for survival analysis and treatment strategies.

Key Points

  • This research aims to explore clonal evolution in myelodysplastic syndromes (MDS) using longitudinal sequencing.
  • Retrospective analysis of 122 MDS patients with paired diagnostic and relapse samples
  • Utilized next-generation sequencing and molecular taxonomy to classify patients
  • Conducted survival analysis using Kaplan-Meier methods and Chi-square tests for categorical comparisons.
  • Significant shifts in molecular clusters observed between diagnosis and relapse
  • Median survival varied across different molecular clusters, with DDX41 group showing longest median overall survival
  • Molecular transitions highlighted the instability in certain clusters impacting patient outcomes.

Cite This Study

Dhillon et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d7a5https://doi.org/10.1182/blood-2025-2066
View Full Paper
Ask AI
Bookmark
Share