Clonal evolution and risk assessment in myelodysplastic syndromes (MDS): A prospective Study of dynamic IPSS-m validation and evolutionary trajectory modeling by the italian MDS foundation (FISIM)
Prospective study demonstrates improved prognostic performance of dynamic IPSS-M in MDS patients for AML risk prediction.
Key Points
This research aims to assess the clonal evolution and risk of progression in myelodysplastic syndromes using the dynamic International Prognostic Scoring System.
Prospective enrollment of adult MDS patients across 28 Italian hospitals.
Collection of clinical and molecular data from peripheral blood and bone marrow.
Application of Cox regression models for validation of IPSS-M and mutation detection accuracy.
Improved predictive performance of dynamic IPSS-M compared to baseline assessment with c-index of 0.80 for overall survival.