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December 8, 2025BloodOpen Access

Defining evolutionary trajectories in myelodysplastic syndromes and integrating them into prognostic models to improve risk stratification: The progevo machine learning approach

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Authors

MVMatteo VillaLLLuca LaninoTHTorsten Haferlach

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Overview

Machine learning improves risk stratification in myelodysplastic syndromes, indicating better prognostic models for leukemia-free survival.

Key Points

  • The research aims to define evolutionary trajectories in myelodysplastic syndromes and improve risk stratification using machine learning.
  • Developed ProgEvo, a machine learning framework for predicting clinical outcomes.
  • Estimated cancer cell fractions from variant allele frequencies corrected for copy number.
  • Conducted evolutionary validation on the GenoMed4All patient cohort.
  • Identified six genes as primary driver mutations and several directional routes significantly associated with leukemia-free survival.
  • IPSS-M-Evo model demonstrated improved prognostic discrimination for leukemia-free survival and overall survival compared to the original IPSS-M model.

Cite This Study

Villa et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d851https://doi.org/10.1182/blood-2025-3847
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clonal evolution and risk assessment in myelodysplastic syndromes (MDS): A prospective Study of dynamic IPSS-m validation and evolutionary trajectory modeling by the italian MDS foundation (FISIM)2025
  2. 2Abstract 6208: Characterization of molecular evolution in myelodysplastic neoplasms2024 · 1 citations
  3. 3Longitudinal genomic and cytogenetic dynamics in myelodysplastic syndromes (MDS): Insights into clonal evolution and disease progression2025
  4. 4Integrated machine learning-based prognostic models for patients with Myelodysplastic Syndromes/neoplasms (MDS)2025
  5. 5Machine learning uncovers invariant evolutionary molecular trajectories in MDS.2025