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December 8, 2025BloodOpen Access

Longitudinal genomic and cytogenetic dynamics in myelodysplastic syndromes (MDS): Insights into clonal evolution and disease progression

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Authors

EBEesha BalarSDSafoora DeihimiSLSelina M. Luger

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Overview

Analysis reveals clonal evolution and somatic mutations influence clinical outcomes in MDS patients, indicating a need for early intervention.

Key Points

  • This research aimed to investigate clonal evolution and genetic changes in myelodysplastic syndromes (MDS).
  • Retrospective analysis of 310 samples from 76 newly diagnosed MDS patients
  • Utilized longitudinal targeted sequencing and cytogenetic profiling
  • Assessed the impact of somatic mutations on disease trajectories and patient outcomes.
  • TP53 and KRAS mutations were identified as crucial in clonal evolution.
  • Approximately 42.1% of patients underwent stem cell transplant (SCT).
  • Stable mutations in epigenetic regulators were observed in 82% of cases.

Cite This Study

Balar et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e41ehttps://doi.org/10.1182/blood-2025-5635
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Deciphering clonal progression in MDS via longitudinal sequencing2025
  2. 2Clonal evolution and risk assessment in myelodysplastic syndromes (MDS): A prospective Study of dynamic IPSS-m validation and evolutionary trajectory modeling by the italian MDS foundation (FISIM)2025
  3. 3Clonal persistence and early cooperative mutations shape transformation in myelofibrosis2025
  4. 4Molecular subclusters across the continuum of myelodysplastic neoplasms and acute myeloid leukaemia define distinct clinical entities2025
  5. 5Abstract 6208: Characterization of molecular evolution in myelodysplastic neoplasms2024 · 1 citations