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December 8, 2025Blood

Integrated machine learning-based prognostic models for patients with Myelodysplastic Syndromes/neoplasms (MDS)

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Authors

XWXin WangZXZefeng XuBJBo Jiang

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Overview

Prognostic models improved overall survival assessment in myelodysplastic syndrome patients, suggesting better clinical outcomes.

Key Points

  • The aim was to develop integrated prognostic models that include patient-related factors to enhance prognosis assessment for MDS.
  • Conducted a study with 687 newly diagnosed MDS patients
  • Utilized random survival forests for model development
  • Employed five-fold cross-validation for model validation
  • Evaluated model performance using C-index, Brier scores, and AUC
  • Achieved C-index of 0.700/0.708 and Brier scores of 0.175/0.140
  • Defined three risk groups with differing median overall survival rates
  • Identified significant performance differences in survival outcomes based on risk stratification
  • Demonstrated improved prognostic accuracy compared to established models

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d904https://doi.org/10.1182/blood-2025-7385
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Enhanced IPSS-m: A comorbidity-integrated model for improved clinical risk stratification in myelodysplastic neoplasms2025
  2. 2IPSS, IPSS-R and IPSS-M had no identical prognostic power depending on treatment in myelodysplastic syndromes2026
  3. 3Prognostic impact of pre-transplant IPSS-m risk downstaging in Myelodysplastic Syndromes2025
  4. 4IPSS-m outperforms IPSS-R in younger adults with Myelodysplastic Syndromes: A retrospective age-stratified analysis2025
  5. 5Validation of the Molecular International Prognostic Scoring System (IPSS-M) for myelodysplastic neoplasms (MDS) and comparison with the revised International Prognostic Scoring System (IPSS-R) in Chinese Population: A Multicenter Retrospective Study.2024 · 1 citations