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December 8, 2025Blood

Enhanced IPSS-m: A comorbidity-integrated model for improved clinical risk stratification in myelodysplastic neoplasms

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Authors

VDVikramjit DhillonJAJeff Justin AguilarSCSikander Chohan

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Overview

Enhanced IPSS-M demonstrates improved risk stratification in myelodysplastic neoplasms by integrating comorbidity metrics, highlighting survival impacts.

Key Points

  • To develop an Enhanced IPSS-M model incorporating comorbidities for improved risk stratification in MDS.
  • Used a training cohort of 236 MDS patients from Karmanos Cancer Institute with comorbidity data.
  • Integrated Charlson Comorbidity Index and ECOG performance status into the IPSS-M framework.
  • Validated model performance against 3,323 patients from the MDS-IWG cohort.
  • Employed a machine learning algorithm to refine the prognostic model.
  • Enhanced IPSS-M achieved a concordance index of 0.692, significantly improving over the baseline IPSS-M (0.595).
  • More than half of patients (51%) were reclassified to higher-risk categories based on comorbidities.
  • Prevalent comorbidities included hypertension (45%) and diabetes mellitus type II (45%).
  • Significant reductions in poor-risk mutations were observed in the training cohort compared to the validation cohort.

Cite This Study

Dhillon et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d85ahttps://doi.org/10.1182/blood-2025-3871
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integrated machine learning-based prognostic models for patients with Myelodysplastic Syndromes/neoplasms (MDS)2025
  2. 2Comparative evaluation of ipss-m and cpss-mol in CMML: Impact of molecular markers on prognosis2025
  3. 3IPSS-m outperforms IPSS-R in younger adults with Myelodysplastic Syndromes: A retrospective age-stratified analysis2025
  4. 4Comparison of the prognostic predictive value of Molecular International Prognostic Scoring System and Revised International Prognostic Scoring System in patients undergoing allogeneic hematopoietic stem cell transplantation for myelodysplastic neoplasms2023 · 5 citations
  5. 5Immune-based risk score derived from bulk and single-cell transcriptomics enhances prognostic stratification in MDS2025