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December 8, 2025BloodOpen Access

Immune-based risk score derived from bulk and single-cell transcriptomics enhances prognostic stratification in MDS

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Authors

ZZZiying ZhangRERosa Andres EjarqueRRRita Antunes Dos Reis

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Overview

This approach enhances risk stratification models using immune signatures and clinical data in MDS, highlighting immune checkpoints.

Key Points

  • To develop a refined immune-based risk score integrating transcriptomics for patient stratification in MDS.
  • Integrated bulk RNA-seq and single-cell CITE-seq for immune signature identification
  • Used single-sample Gene Set Enrichment Analysis (ssGSEA) scoring method
  • Employed LASSO for signature selection and Cox proportional hazard model for risk score calculation
  • Validated findings across three independent MDS cohorts
  • Improved prognostication and patient stratification in MDS using immune signatures
  • Identified distinct immune risk groups correlating with survival outcomes
  • Demonstrated high correlation of immune signature scores with flow cytometry estimates
  • Validated immune characteristics of risk groups in an independent cohort

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236cfffhttps://doi.org/10.1182/blood-2025-115
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