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December 8, 2025BloodOpen Access

Searching for a myelodysplastic syndrome stem cells (MDS-SCs) signature by flow cytometry: Toward a new prognostic tool?

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Authors

ASAnna SicuranzaMCMariachiara CuccaroASAdele Santoni

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Overview

Flow cytometry analysis reveals MDS stem cells indicating potential progression to AML in patients.

Key Points

  • This research aims to explore the stem cell signature in myelodysplastic syndromes (MDS) to improve prognosis.
  • Collected bone marrow samples from patients with suspected MDS.
  • Utilized flow cytometry to analyze CD34+ cells and identify HSCs and LSCs subsets.
  • Conducted cytomorphology, histopathology, cytogenetic, and molecular tests for confirmation.
  • Confirmed MDS diagnosis in 87% of patients based on cytomorphology and cytogenetics.
  • Stratified 55 MDS patients into four groups based on presence of HSCs and LSCs.
  • Identified mutations associated with MDS pathogenesis and potential progression to AML.

Cite This Study

Sicuranza et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236da2bhttps://doi.org/10.1182/blood-2025-5615
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Myelodysplastic neoplasms dissected into indolent, leukaemic and unfavourable subtypes by computational clustering of haematopoietic stem and progenitor cells2024 · 9 citations
  2. 2Computing cell state discriminates the aberrant hematopoiesis and activated microenvironment in Myelodysplastic syndrome (MDS) through a single cell genomic study2024 · 5 citations
  3. 3Functional Characterization of Myelodysplastic Syndrome by Multiparameter Flow Cytometry: The Clinical Synergy Between Ki-67 and Bcl-2 and Their Potential Role in Diagnostics and Personalized Therapy2026
  4. 4Single-cell multiomics reveals molecular identities and clonal dynamics of MRD progression in Myelodysplastic Syndromes after stem cell transplant2025
  5. 5Molecular subclusters across the continuum of myelodysplastic neoplasms and acute myeloid leukaemia define distinct clinical entities2025