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December 8, 2025BloodOpen Access

Macrophage CD38 overexpression drives primary platelet engraftment failure via paracrine suppression following allogeneic hematopoietic stem cell transplantation

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Authors

HHHua HeQSQin Shi

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Overview

Research demonstrates macrophage CD38 drives platelet engraftment failure in thrombocytopenia, highlighting potential therapeutic approaches.

Key Points

  • This research aims to elucidate the role of macrophage CD38 in driving thrombocytopenia following hematopoietic stem cell transplantation.
  • Quantified CD38+ monocytes/macrophages in patients via flow cytometry
  • Assessed cytokine profiles with MSD U-PLEX and ELISA
  • Used myeloid-specific CD38-knockout mice for mechanistic studies
  • Conducted transplantation models to monitor hematologic recovery
  • Applied single-cell RNA sequencing to analyze hematopoietic lineage.
  • Elevated CD38+ monocyte/macrophage proportions correlate with lower platelet counts and megakaryocyte numbers
  • CD38-knockout mice showed enhanced megakaryocyte differentiation and recovery
  • Pro-inflammatory cytokines increased; anti-inflammatory mediators and transcription factors decreased
  • CD38 inhibition accelerated platelet recovery in transplantation models.

Cite This Study

He et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d880https://doi.org/10.1182/blood-2025-4202
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tumor necrosis factor-alpha (TNFα) drives pathologic platelet hyperreactivity through signaling on hematopoietic stem/progenitor cells and expansion of canonical megakaryocytic progenitors.2025
  2. 2High-dimensional profiling reveals predominant depletion of NK cell effector phenotypes in relapsed/refractory multiple myeloma patients treated with anti-CD38 therapy2025
  3. 3Multimodal analysis of CD38 in T-cell Acute Lymphoblastic Leukemia Identifies Combinatorial Therapeutic Strategies2026
  4. 4CD38 Inhibitor 78c Attenuates Pro-Inflammatory Cytokine Expression and Osteoclastogenesis in Macrophages2024 · 5 citations
  5. 5Targeting CD38 Across Autoimmune and Plasma Cell–Driven Immune-Mediated Diseases: Rationale, Clinical Evidence, and Emerging Therapeutic Landscape2026