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December 8, 2025BloodOpen Access

Prevalence, clinical correlates and clonal inferences of concurrent splicing factor mutations in patients with myeloid neoplasms

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Authors

TLTerra LashoCFChristy FinkePPPankaj Pradeep

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Overview

Analysis reports higher incidence of concurrent splicing factor mutations in myeloid neoplasms, implying potential clonal relationships.

Key Points

  • This study aims to explore the prevalence and clonal relationships of concurrent splicing factor mutations in myeloid neoplasms.
  • Assessed 3,369 myeloid next generation sequencing results from 2,500 adult patients.
  • Categorized patients with concurrent splicing factor mutations and evaluated co-dominance.
  • Used Fisher's exact testing to analyze hotspot variants and co-dominant combinations.
  • Identified 2,331 patients with at least one pathogenic splicing factor mutation.
  • 6.7% of patients had multiple splicing factor mutations, with some exhibiting co-dominant CCFs.
  • Lower hemoglobin levels were associated with co-dominant multi-splicing factor mutations.

Cite This Study

Lasho et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d8a5https://doi.org/10.1182/blood-2025-5650
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