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December 8, 2025BloodOpen Access

Additional myelodysplasia-related genes mutations affected the clinical presentations and prognosis of patients with SRSF2/TET2 co-mutations

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Authors

VJVeena JajooUniversity of South FloridaHZHailing ZhangMoffitt Cancer CenterRSRichard ShaoUniversity of Central Florida

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Overview

Study shows clinical implications of additional gene mutations in myelodysplastic/myeloproliferative neoplasm, suggesting poorer prognosis in chronic myelomonocytic leukemia.

Key Points

  • This research aims to determine how additional myelodysplasia-related gene mutations influence clinical outcomes in patients with SRSF2/TET2 co-mutations.
  • Retrospective analysis of 412 patients with SRSF2/TET2 co-mutations from NGS database.
  • Collection of demographic, pathologic, cytogenetic, and FISH data under IRB approval.
  • Assessment of overall survival using Kaplan-Meier and Log Rank tests.
  • 55% of patients had at least one additional myelodysplasia-related gene mutation.
  • Patients with additional mutations showed significantly lower overall survival compared to those without.
  • Mutations in ASXL1, BCOR, STAG2, and ZRSR2 were associated with specific diagnoses and poorer prognoses.

Cite This Study

Jajoo et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d792https://doi.org/10.1182/blood-2025-2069
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characterisation and prognostic impact of ZRSR2 mutations in myeloid neoplasms2024
  2. 2Prognostic implications of myelodysplasia-related gene mutations in NPM1-mutated acute myeloid leukemia: a systematic review and meta-analysis2026
  3. 3Prognostic impact of myelodysplasia-related gene mutations in FLT3-ITD-mutated acute myeloid leukemia2026 · 1 citations
  4. 4Unifying the classification of acute myeloid leukemia, myelodysplasia-related: A multi-institutional experience2025 · 1 citations
  5. 5Association between gene mutations and certain blood cell indices in patients diagnosed with myelodysplastic neoplasms2024