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December 8, 2025BloodOpen Access

Unifying the classification of acute myeloid leukemia, myelodysplasia-related: A multi-institutional experience

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Authors

ESEytan M. SteinWXWenbin Xiao

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Overview

Multivariate analysis reveals RUNX1 and gene mutations are key prognostic factors in AML-MR patients.

Key Points

  • To refine the classification of acute myeloid leukemia myelodysplasia-related (AML-MR) and assess its outcomes.
  • Retrospective review of 619 AML patients from two institutions
  • Analysis of clinical, histopathological, and molecular characteristics
  • Overall survival estimated by Kaplan-Meier; associations assessed by Cox proportional-hazard models
  • Identified RUNX1 as a critical gene mutation in AML-MR classification
  • Similar overall survival across AML-MR subgroups irrespective of the algorithm used
  • Multivariate analysis highlighted performance status and stem cell transplant as significant prognostic factors

Cite This Study

Stein et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dc4fhttps://doi.org/10.1182/blood-2025-219
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