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December 8, 2025Blood

Celmods potently inhibit m-MDSC induction by targeting IL-10 and MIF in multiple myeloma

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Authors

HNHiroaki Nagata

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Overview

Experiments demonstrate CELMoDs reduce M-MDSC induction and modulate immune responses in myeloma, suggesting therapeutic potential.

Key Points

  • To investigate the effects of CELMoDs on M-MDSC induction in multiple myeloma and understand their mechanism of action.
  • Conducted 96-hour co-culture experiments with HMCLs and PBMCs from healthy donors.
  • Added CELMoDs and POM at non-cytotoxic concentrations to evaluate their impact on M-MDSC induction.
  • Identified M-MDSC populations and analyzed molecular changes using RNA microarray and cytokine assays.
  • IBER, MEZI, and POM maintained over 70% viability in HMCLs after treatment while reducing M-MDSC induction in a dose-dependent manner.
  • CELMoDs inhibited M-MDSC induction at significantly lower concentrations compared to POM, indicating higher potency.
  • Transcriptomic analysis revealed opposing effects of CELMoDs on inflammatory gene expression in myeloma cells and PBMCs.

Cite This Study

Hiroaki Nagata (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d91chttps://doi.org/10.1182/blood-2025-7447
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