Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Clonal dynamics of FLT3-ITD positive acute myeloid leukemia following relapse after allogeneic stem cell transplantation

View Full Paper
Ask AI
Bookmark
Share

Authors

ADAlp Dinc-OranKMKhaoula MazouziNDNaval Daver

Discussion

Loading...

Member takes

Overview

Retrospective analysis reveals maintenance therapy influences mutation patterns in FLT3-ITD AML relapse post alloSCT, suggesting new treatment strategies.

Key Points

  • This research investigates clonal dynamics and mutation patterns in FLT3-ITD AML post-relapse after allogeneic stem cell transplantation.
  • Retrospective analysis of pre- and post-transplant relapsed AML samples
  • Evaluation of cytomolecular landscape of FLT3-ITD AML
  • Assessment of FLT3-ITD length using capillary electrophoresis
  • Comparison of mutations before and after transplantation
  • 67 out of 153 patients relapsed post-transplant, with 82.5% relapses occurring within the first year
  • 12 patients received post-transplant maintenance therapy with FLT3 inhibitors
  • At relapse, 61.9% of patients retained at least one FLT3-ITD clone, and 22.5% showed undetectable levels of FLT3-ITD
  • Emergence of new mutations and changes in existing mutations were noted, highlighting clonal persistence and alterations.

Cite This Study

Dinc-Oran et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d95dhttps://doi.org/10.1182/blood-2025-592
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1FLT3-ITD with NPM1 and/or DNMT3A co-mutations in acute myeloid leukemia: prognostic significance and the role of maintenance therapy post-transplantation2025 · 1 citations
  2. 2Detection of minute FLT3-ITD clones at day +30 post-allo-HSCT predicts high relapse risk and informs maintenance therapy in AML: A niche cohort study2025
  3. 3Mutational landscape changes of AML in patients relapsing after allogeneic hematopoietic cell transplantation2026 · 2 citations
  4. 4Impact of initial FLT3-ITD mutated clone numbers on clinical outcomes in Acute Myeloid Leukemia2025
  5. 5Recrudescence of a FLT3 wild-type CMML clone after allogeneic stem cell transplant for FLT3-ITD acute myeloid leukemia.2026