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December 8, 2025BloodOpen Access

Impact of initial FLT3-ITD mutated clone numbers on clinical outcomes in Acute Myeloid Leukemia

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Authors

SPSilvia ParkCMChang‐Ki Min

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Overview

Analysis reveals lower response rates and poorer survival in AML with multiple FLT3-ITD clones, indicating clonal heterogeneity as a biomarker.

Key Points

  • This study investigates the impact of FLT3-ITD mutated clone numbers on treatment outcomes in Acute Myeloid Leukemia patients.
  • Retrospective analysis of adult AML patients with FLT3-ITD mutations diagnosed from 2017 to 2024.
  • Patients classified into monoclone and multiclone groups based on FLT3-ITD clones.
  • Clinical characteristics, treatment modalities, and survival outcomes were compared using statistical methods.
  • Multiclone group had a median overall survival of 1.6 years, shorter than the monoclone group's 1.8 years (p = 0.046).
  • Higher percentage of bone marrow blasts at diagnosis in the multiclone group (median 90% vs. 84%, p = 0.032).
  • Lower final response rates in multiclone group (54.8% vs. 73.1%, p = 0.026).

Cite This Study

Park et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e470https://doi.org/10.1182/blood-2025-1638
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diagnostic evaluation methods and prognostic impact of FLT3-ITD microclones in Acute Myeloid Leukemia (AML): A retrospective multicenter study on behalf of the EHA AML-specialized working group (SWG)2025 · 1 citations
  2. 2Clonal dynamics of FLT3-ITD positive acute myeloid leukemia following relapse after allogeneic stem cell transplantation2025
  3. 3Prognostic impact of co-occurring FLT3 mutations across molecular subgroups in intensively treated acute myeloid leukemia: Insights from real-world genomic data2025
  4. 4Clonal timing of FLT3-ITD dictates evolutionary trajectory and phenotypic heterogeneity in acute myeloid leukemia2025
  5. 5DNMT3A, NPM1, and FLT3-ITD triple-mutated AML has a favorable prognosis in the era of FLT3 inhibitors2025 · 3 citations