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December 8, 2025Blood

Prognostic impact of co-occurring FLT3 mutations across molecular subgroups in intensively treated acute myeloid leukemia: Insights from real-world genomic data

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Authors

YCYu-Sung ChangYWYuwen WangCYChi‐Yuan Yao

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Overview

Retrospective analysis shows FLT3 mutations influence prognosis in AML, suggesting improved risk stratification and treatment pathways.

Key Points

  • This research aims to investigate the prognostic impact of FLT3 mutations across molecular subgroups in acute myeloid leukemia (AML).
  • Retrospective analysis of 1,151 intensively treated de novo AML patients
  • Examination of FLT3 mutation types and co-mutations
  • RNA sequencing performed in 427 cases
  • Multivariable Cox models assessed overall survival
  • FLT3 ITD mutation showed poorer overall survival compared to FLT3 wild type
  • Co-occurrence of mutations such as FLT3 ITD and TKD resulted in significantly shorter overall survival
  • Transcriptomic analysis revealed pathways involved in oxidative phosphorylation and DNA repair

Cite This Study

Chang et al. (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236e043https://doi.org/10.1182/blood-2025-5249
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic factors for newly diagnosed Acute Myeloid Leukemia with FLT3-TKD - a multicenter retrospective study2025
  2. 2DNMT3A, NPM1, and FLT3-ITD triple-mutated AML has a favorable prognosis in the era of FLT3 inhibitors2025 · 3 citations
  3. 3Diagnostic evaluation methods and prognostic impact of FLT3-ITD microclones in Acute Myeloid Leukemia (AML): A retrospective multicenter study on behalf of the EHA AML-specialized working group (SWG)2025 · 1 citations
  4. 4Outcomes of patients with newly diagnosed acute myeloid leukemia with FLT3-tyrosine kinase domain mutations: Prognostic implications of NPM1 co-mutation.2025 · 3 citations
  5. 5Prognostic relevance of multiparameter flow cytometry-based MRD assessment in patients with FLT3-ITD mutated AML considering concomitant mutations including DNMT3A/NPM1/WT1 mutation2025 · 1 citations